GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4597304 | 1 | rs4597304 | chr16:85055741 | ZDHHC7 | chr16:85008067-85045141:- | 0.33 | 5.5 | 6.25E-8 | Dysphagia |
| THCA | cis | rs9790314 | 1 | rs4597724 | chr3:160963110 | NMD3 | chr3:160939099-160971319:+ | -0.11 | -3.72 | 0.000221 | Morning vs. evening chronotype |
| THCA | cis | rs465969 | 1 | rs459888 | chr6:111651156 | KIAA1919 | chr6:111580482-111590259:+ | -0.43 | -5.15 | 3.72E-7 | Psoriasis |
| THCA | cis | rs9386791 | 1 | rs4601178 | chr6:109611246 | CD164 | chr6:109687718-109703762:- | 0.13 | 3.41 | 0.000702 | Red blood cell traits |
| THCA | cis | rs4141404 | 1 | rs4603880 | chr22:31744721 | RNF185 | chr22:31556138-31603004:+ | 0.25 | 4.62 | 4.84E-6 | Paclitaxel-induced neuropathy |
| THCA | cis | rs11734488 | 1 | rs4604102 | chr4:139119779 | SLC7A11 | chr4:139085248-139163503:- | 0.23 | 4.71 | 3.19E-6 | Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect) |
| THCA | cis | rs11190604 | 1 | rs4604805 | chr10:102261409 | SEC31B | chr10:102246403-102289636:- | -0.27 | -8.82 | 2.11E-17 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs7112513 | 1 | rs4604928 | chr11:117044203 | PCSK7 | chr11:117075789-117102811:- | -0.4 | -6.89 | 1.82E-11 | Protein quantitative trait loci |
| THCA | cis | rs9790314 | 1 | rs460508 | chr3:161091089 | NMD3 | chr3:160939099-160971319:+ | 0.11 | 3.67 | 0.000266 | Morning vs. evening chronotype |
| THCA | cis | rs4605213 | 1 | rs4605213 | chr17:49244747 | NME1-NME2 | chr17:49230920-49249104:+ | 0.32 | 6.46 | 2.66E-10 | Height |
| THCA | cis | rs4605213 | 1 | rs4605213 | chr17:49244747 | NME2 | chr17:49242891-49249104:+ | -0.14 | -5.15 | 3.81E-7 | Height |
| THCA | cis | rs11734488 | 1 | rs4605709 | chr4:139119926 | SLC7A11 | chr4:139085248-139163503:- | 0.22 | 4.45 | 1.09E-5 | Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect) |
| THCA | cis | rs4606360 | 1 | rs4606360 | chr1:173699007 | KLHL20 | chr1:173684080-173755838:+ | 0.12 | 3.41 | 0.000694 | Subjective well-being |
| THCA | cis | rs4606360 | 1 | rs4606360 | chr1:173699007 | RABGAP1L | chr1:174128634-174959724:+ | 0.14 | 3.53 | 0.000449 | Subjective well-being |
| THCA | cis | rs4606360 | 1 | rs4606360 | chr1:173699007 | SERPINC1 | chr1:173872943-173886516:- | 0.3 | 4.97 | 9.31E-7 | Subjective well-being |